Granulars as important raw material in food, chemical and pharmaceutical industries in nowadays, it is widely used. Many people asking why the materials made to granular? What is the advantage of granular? Here we analysis in following 3 aspects to show the advantages of medicine granular, Feed pellet, and Plastic granular.
The concept of Chinese medicine formula granules first appeared in the early 1920s, and its industrialization was initiated in Japan, South Korea, and Taiwan in the 1960s and 1970s. The leading enterprise of traditional Chinese medicine (TCM) formula granules in mainland China is Jiangsu Tianjiang Pharmaceutical. In 1993, Tianjiang Pharmaceutical declared the scientific research project of TCM formula granules, but in 2016, only 503 types of TCM granules from Shenwei Pharmaceutical were included in the medical insurance catalog in Hebei Province. Meanwhile, Tianjiang Pharmaceutical, Yifang Pharmaceutical, Sichuan New Green Pharmaceutical, Nanning Peili Pharmaceutical, China Resources Sanjiu Pharmaceutical, and Kangrentang Pharmaceutical were not selected.
In 2001, the supervision meeting held in Hangzhou formally adopted the name “Chinese medicine formula particles.” The Interim Provisions for the Management of Chinese Medicine Formula Particles, issued at the same time, included these particles within the scope of Chinese medicine decoction pieces management. It introduced approval number management and required three mandatory declaration conditions for pilot production enterprises: (1) The manufacturer must hold the Drug Manufacturing Enterprise License and be authorized to produce granules; (2) Research on Chinese medicine formula granules must be approved by provincial and ministerial scientific research projects and achieve phased results (providing project approval documents, contract letters, or acceptance certificates); and (3) Production enterprises must develop more than 400 varieties (the third condition discouraged over 800 pharmaceutical decoction piece production enterprises, and only 6 successfully passed as TCM formula granule pilot enterprises).
In June 2013, the CFDA issued a notice on the strict processing standards of Chinese medicine decoction pieces and the management of Chinese medicine formula particles pilot study. The release of the Management Measures for Chinese Medicine Formula Particles (Draft for Comments) in December 2015 formed the initial management and use supervision system for Chinese medicine formula particles.
Advantages and disadvantages of Chinese Herbal Formula Granules
The eight characteristics of Chinese medicine formula granules successfully avoid the disadvantages of traditional Chinese medicine:
Advantages:
Convenience: Granules purify drugs. Compared with herbs, granules require a smaller dosage to achieve the same effect, saving the trouble of decocting. It is also easier to take, carry, store, and transport, making it more attractive to patients. Mixing the granules with warm boiled water eliminates the trouble of decocting traditional Chinese medicine.
Stability: Suitable for industrial production, granules can be made into color, aroma, and taste preparations. The quality of granules is more stable compared to traditional Chinese medicine that needs boiling.
Taste: Additives can be added to adjust the taste, making the medicine more palatable, especially for children.
Faster absorption and effectiveness.
Coating: If necessary, granules may be coated or made into sustained-release preparations.
Safety and hygiene: Moisture-proof and mothproof properties, with clear printing of drug names, contribute to the cleanliness and management of traditional Chinese medicine.
Compatibility with modern lifestyles: Formula granules are more adaptable to modern fast-paced lifestyles and simplified life attitudes.
Variety of dosage forms: Fine packaging with different dosage forms allows for the adjustment of infusion concentration according to personal preference.
Disadvantages: Concerns Regarding Chinese Medicine Formula Granules.
Traditional Chinese medicine formula granules are processed from a single flavor of medicinal materials. While this approach may be impeccable for traditional Chinese medicine, many industry experts express concerns about adjusting traditional Chinese medicine compounds. Further development also faces limitations.
In the Chinese medicine community, it is generally believed that the pharmacological effect of Chinese herbal compounds is not a simple sum of the effective ingredients of individual medicinal materials. Adsorption, precipitation, solubilization, and other interactions occur between medicinal ingredients during decocting, causing changes in composition. For example, bupleurum combined with ginseng enhances the solubility of bupleurum’s pharmacodynamic components. Similarly, aconitum combined with licorice reduces the dissolution rate of aconitum’s toxic component aconitine. The production of new compounds through hydrolysis, oxidation, and reduction of TCM components also presents unsolved problems in the pilot production of TCM formula granules.
It is uncertain whether the simple mixing of TCM formula particles can replicate the effects of traditional decoction methods. After over 20 years, industry concerns remain unresolved.
What is a Fluid Bed Granulator? Fluid Bed Granulator is a machine mainly used for pharmaceutical granulation and coating, characterized by safe operation and high degree of automation. Fluid Bed Granulator Working Principle The powder material is placed into the closed container of the hopper. Due to the action of the hot airflow, the powder…
What is a Dry granulating machine? A dry granulating machine uses dry roller press technology to compress or form blocks from powder materials with a water content of ≤5%. The blocks are then crushed and screened to produce granular materials that meet usage requirements. Dry granulating machine Working Principle It is based on the principle…
What is a granulating machine? A granulating machine is an industrial device used to shape powdered or granular raw materials through the application of pressure and friction to form uniform or solid particles. Granulating Machine including various types, such as super granulator, super mixer granulator, Rotary type, Swing Type Granulator, Grinding and Granulating machine, Dry…
Swing Granulator Parameter: A Swing Granulator is a machine for making pellets from dry material. The Swing Granulator will be wet powder or block dry material developed into the required particles, mainly wet powder mixture, under the positive and reverse rotation of the rotating drum, forced through the screen and made of particles special equipment….
Rotary Granulator Parameter: Model Capacity(KG/H) Granulator diameter(mm) Dimension(mm L*W*H) Weight(KG) Motor Power(KW) Knife Size(MM) BJB-250 100-200 1.0-3 750*540*1400 350 3/4 250 BJB-350 150-350 1.0-3 800*650*1400 400 5.5/7/5 300 Rotary Granulator Price: The Rotary Granulator according to different model is around $580~$12,000. For more price information Please click. Rotary Granulator Meaning： Rotary Granulator machine and material…
Super Granulation Definition & Meaning: A Super Granulator is also called “pelletizer”. It is an industrial device used to shape powdered or granular raw materials through the action of pressure and friction to form uniform particles or solid particles. This equipment is used in many industries, such as agriculture, chemical, pharmaceutical, building materials, food and…
Additionally, Chinese medicine formula particles have the following disadvantages:
High preservation requirements: Granules have high packaging requirements; if the granules are unsealed, they are more susceptible to moisture, shortening their shelf life.
Granules are generally taken in water: Improper brewing methods can make some granules difficult to dissolve, potentially making the drug hard to swallow. Soak granules in warm water for better dissolution. If a small amount of sediment appears, boiling water can be used again. Avoid taking granules that have an odor, caking, or mold.
Patent system barriers: Single TCM formula particles are protected by patents, making it difficult to overcome these barriers in the short term.
Hygroscopicity: Some varieties are hygroscopic, which can cause caking; others may have loose particles and more fine powder.
Introduction of TCM Compound Granules: TCM compound granules combine the advantages of TCM formula granules and better align with the pharmacology theory of TCM compounds. By combining traditional Chinese medicine with modern pharmaceutical technology, they are more suitable for the contemporary pharmaceutical market. Chen Kaixian, a member of the National Committee of the Chinese People’s Political Consultative Conference (CPPCC), suggested that the state should allow for the production, filing, supervision, and use of traditional Chinese medicine or classic prescription co-decoction granules under drug management regulations. This would promote the clinical application of traditional Chinese medicine compounds made of granules and encourage the development of the traditional Chinese medicine industry.
The advantages of Feed Pellet:
Pellet feed has the following advantages:
Comprehensive nutrition and digestion absorption: Pellet feed contains a variety of nutrients required by animals, and these nutrients are evenly distributed in the pellets, helping to improve digestibility and utilization of the feed.
Reduced waste: Pellet feed is less likely to scatter during feeding, which helps to minimize feed waste.
Cleanliness: The surface of pellet feed is smoother than that of powder feed, which reduces the risk of bacteria and eggs breeding and helps maintain a clean feeding environment.
Ease of transport and storage: Pellet feed has a high density and small size, making it easy to store and transport. It is also less prone to classification.
Prevention of picky eating: Pellet feed can prevent animals from being picky eaters, ensuring a balanced intake of nutrients.
Improved returns: The pelleting process involves moisture, temperature, and pressure, which cause physicochemical reactions such as starch gelatinization and increased enzyme activity, leading to improved feed conversion.
Nutritional level control: Feed formulations and particle sizes can be adjusted as needed to meet the nutritional needs of different animals.
Reduction of automatic grading of feed ingredients: In the process of storing and transporting powdered feed, different particle sizes and weights can cause separation. This issue is eliminated when using pellets.
Reduced risk of salmonella: The high-temperature steam conditioning and granulation process can kill salmonella in animal feed.
Despite these advantages, pellet feed can be relatively expensive to produce. Therefore, when choosing pellet feed, it is important to consider its benefits and costs comprehensively.
Avoids Picky Eating in Animals: The compound feed formula contains a variety of raw materials and comprehensive nutrition, which prevents animals from selecting their preferred food from the powder and rejecting other ingredients. Pellet feed maintains uniformity during storage, transportation, and feeding, reducing feeding loss by 8-10%.
Increases Feed Yield: During the granulation process, the combination of water, temperature, and pressure induces some physical and chemical reactions in the feed, such as starch gelatinization and enhanced enzyme activity. This allows animals to digest the feed more effectively, leading to weight gain. Feeding birds and pigs with pellets can increase feed conversion (i.e., efficiency) by 10-12% compared to meal feed. The average daily weight gain is 4%, and the feed-to-meat ratio is 6%. Feeding chickens can reduce the feed-to-meat ratio by 3-10%.
More Economical Storage and Transportation: Granulation increases the bulk density of feed by 40-100%, reducing storage capacity and transportation costs.
Good Flowability and Easy Management: Many powders, especially those with low specific gravity and fluffy feeds, as well as those with molasses, high fat, or urea content, often stick to the sides of feed banks. However, pellet feed has good flowability and rarely causes adhesion. As a result, pellet feed is preferred on large-scale dairy or poultry farms that use automatic feeders.
Reduces Automatic Classification of Feed Ingredients and Environmental Pollution: During powder storage and transportation, classification can occur due to differences in the volume and quality of various powders. After granulation, feed components do not segregate, and the particles produce much less dust and pollution to air and water compared to powder during the feeding process.
Eliminates Salmonella in Animal Feed: Salmonella can remain in the tissues of animals after ingestion, and people who consume infected animals may contract Salmonella enteropathy. The use of steam high-temperature conditioning and granulation can eliminate Salmonella in animal feed.
Advantages and Disadvantages of Plastic Particles
Advantages of Plastic Particles
Lightweight: Plastic particles are much lighter in weight compared to metal, wood, and other raw materials. This significantly reduces the weight of the product, making handling and use easier.
Low Cost: Plastic particles are generally more affordable compared to other raw materials, making them cost-effective and widely used in various industries.
Stable Performance: Plastic particles exhibit stable performance, are easy to control, and can be customized to meet different usage needs.
Good Processing Performance: Plastic particles offer excellent processing performance and can be molded through various methods such as injection molding, extrusion molding, and pressing molding to suit different industry requirements.
Disadvantages of Plastic Particles
Difficult to Dispose of: Disposing of used plastic products can be challenging. While recycling is an option, it requires special treatment for effective recovery, and recycling rates may be relatively low.
Environmental Pollution: Plastic processing can generate harmful gases and waste. Improper handling of these byproducts can lead to environmental pollution.
Susceptibility to Aging: Plastic particles can undergo chemical reactions with oxygen, ultraviolet light, and humidity, leading to aging, deformation, and a shorter lifespan.
Low Durability: Plastic products generally lack the high strength of metal materials, making them prone to mechanical damage and deformation.
Conclusion
In conclusion, particles are widely used in industrial production due to their many advantages. However, their disadvantages and limitations should be carefully considered. It’s essential to balance product quality with environmental protection and efficient resource use to ensure the sustainable production and use of products. LKMixer are manufacturer for granulator, please contact us for more information.
About LKMixer
LKMixer is a professional manufacturer for fertilizer production line, grinder, mixer and granulator, shredder. These machines are widely used in food, pharmaceutical, cosmetic, health care products and chemical industries. The Food materials like Peanut, mushroom, seeds, potato, bean, tobacco, salt, cannabis, tea, Sugar, corn, Coffee, rice, pepper, grain as so on. Grinders have many types such as Pulse Dust Grinder which suitable for zero pollution environment, Turbine Mill which is suitable for coffee bean, 12-120mesh all can meet, Ultrafine Grinding Mill covers 80-200mesh, and also Winnowing Dust Grinder or other grinding machines like SF Hammer. Welcome to contact us for details. Contact us for more information. Proposal, catalog, quotation. Mobile/WhatsApp: +86 18019763531 Tel: +86 21 66037855 Email: sales@lkmixer.com
We have 20 years manufacturing experiences; 15600 cubic meters factory area; 5000sets annual capacity; 55 professional engineers;
What’s your main maket?
South America: Brazil, Colombia, Peru, Bolivia, Uruguay, Paraguay ;Romania; USA with UL Certification Middle East: Saudi, Arabia, Oman, Turkey Europe: Russia, Australia, Belarus, Ukraine, Poland
Can you support OEM?
– Yes, OEM or ODM. Machine can be customized according to customer detail requirement, including capacity and voltages, motor certifications. – Drawing and raw materials also can be customized.
We majorly produce CRUSHER, GRINDER, MIXER, and also have auxiliary machines like DRYER, GRANULATOR, VIBRATING SIFTER, CONVEYOR, etc. We can customize whole production line according to your capacity, material, output sizes of mesh and mm of granule and powder.
CAN YOU GIVE ME GUIDE ON OTHER MACHINE ? TO FULL MY PRODUCTION LINE
YES ! Our f have factory build more than 20 years now, we can design and customize whole line, besides of the grinding machine, mixing machine, we can also fully support to provide the washing machine, cutting machine, drying machine, packing machine, filling machine. Though we are not producing these machine, but our brother companies co-work together for over 20 years, we have rich experience in providing you a full effective production line, fully automatically or semi-automatically.
HOW TO VISIT YOUR COMPANY?
Our Factory located in Jiangsu Province, very near to Shanghai, you can fly to Shanghai Pudong Airport, we pick you up and take you by car 2 hours ride, can reach our factory, welcome your visit.
WHAT’S YOUR BEFORE & AFTER SERVICE ?
1) Before your purchasing, we need to know your detail request, such as what kind of material you want to grind and mixing, what final product powder or granule you want to reach. Because different material and powder sizes request of different machine to do. We can provide professional advice and rich experience help to choose machine. Most of the products we have already did before for other customer, trail test or run mass production, so we knows which machine is best in performance of grinding and mixing. This is of very importance in helping you choose the right model. We also wish this can help our customer a lot. Even the material we didn’t do before, we will prepare the same material and to do the trail test and send video to you for your reference. 2) One Year guarantee of machine quality. If the machine have problem within one year, we will send you the spare parts to you for replacement, but this not including the damage caused by human causes. We also have 24 hours on line guide for customer, if you have operation difficulty, we will guide by video and on line communication with our engineer for your emergency debug. 3) For small machine, we sell with whole machine, it’s no need to install, and easy to operation, no problems for operation. While for large machine, its’s also not difficult to install with video guideline, but if you need, we can assign our technicians to go abroad, the round ticket, food and residents will be paid by customer.
HOW ABOUT YOUR PAYMENT TERM?
Our payment term is T/T. 50% payment in advance, rest of 50% payment finish before the goods shipped. When we finish the machine production we will do trail test and run the machine take videos for your green light. You pay the rest of 50% payment then.
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You may also interest in: About LKMixer LKMixer is a professional manufacturer for fertilizer production line, grinder, mixer and granulator, shredder. These machines are widely used in food, pharmaceutical, cosmetic, health care products and chemical industries. The Food materials like Peanut, mushroom, seeds, potato, bean, tobacco, salt, cannabis, tea, Sugar, corn, Coffee, rice, pepper, grain as…
WCH Double Pulp Tank Mixer Electric Mixer Tank for Sale (Stainless Steel): Universal Grinder Youtube Video (See More) About LKMixer LKMixer is a professional manufacturer for fertilizer production line, grinder, mixer and granulator, shredder. These machines are widely used in food, pharmaceutical, cosmetic, health care products and chemical industries. The Food materials like Peanut, mushroom, seeds,…
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Industrial Dual Spiral Mixer Universal Grinder Youtube Video (See More) About LKMixer LKMixer is a professional manufacturer for fertilizer production line, grinder, mixer and granulator, shredder. These machines are widely used in food, pharmaceutical, cosmetic, health care products and chemical industries. The Food materials like Peanut, mushroom, seeds, potato, bean, tobacco, salt, cannabis, tea, Sugar, corn,…
